Faculty
SELF-INTRODUCTION：
After completing his B.E. and Ph.D. at the National University of Singapore with a full scholarship from the Ministry of Education of Singapore, he became a researcher at the Singapore-MIT Alliance for Research and Technology and School of Biological Sciences, College of Science, Nanyang Technological University, Singapore.
In recent years, he has published several articles with high impact as first or corresponding author (including co-authorship), in Gastroenterology, Cell Research, Cell Host & Microbe, American Journal of Respiratory and Critical Care Medicine, Cell Report, mBio, ACS Applied Materials & Interfaces, etc. He has received fundings from the National Natural Science Foundation of China (NSFC), the Guangdong Provincial Natural Science Foundation of China (GPNSC), and the Shenzhen Science and Technology Innovation Commission's Emergency Prevention and Control of Novel Coronavirus Infection project.
EDUCATION:
2011/01–2016/01 National University of Singapore Ph.D.
2004/08–2008/06 National University of Singapore B.E.
WOKRING EXPERIENCE:
2022/03-now Southern University of Science and Technology Assistant professor
2018-2022 Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Associate professor
HONORS AND AWARDS:
2019 Overseas High-Caliber Personnel
2015 Gold Prize for Oral Presentation in Postgraduate Category, the Biomedical Engineering Society 9th Scientific Meeting (BES9SM), Singapore
2012 Young Investigator Scholarship, Asia-Pacific Congress of Medical Virology (APCMV)
2012 Golden Award for Poster Presentation, the Biomedical Engineering Society 6th Scientific Meeting (BES6SM), Singapore
RESEARCH:
1)The mechanisms of microbial-host interaction using organoids, primary cell culture models, animal models, and the clinical samples, which is combined with clinical applications for the development of novel diagnostic and therapeutic approaches.
2)Protect and reconstruct epithelial and vascular endothelial physical barriers with monoclonal antibody therapy and stem cell therapy accordingly.
MANUSCRIPT REVIEWER AND EDITOR：
Military Medical Research, Young Editorial Board
PUBLICATIONS：
1. Xu, G., Li, Y., Zhang, S., Peng, H., Wang, Y., Li, D., Jin, T., He, Z., Tong, Y., Qi, C., Wu, G., Dong, K., Gou, J., Liu, Y., Xiao, T., Qu, J., Li,L. （Corresponding author）, Liu, L., Zhao, P., Zhang, Z., Yuan, J.. (2021) SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Research. 0:1 – 14. (IF = 25.617)
2. He,Y., Qu, J., Wei, L., Liao, S., Zheng, N., Liu, Y., Wang, X., Jing, Y., Shen, C.K., Ji, C., Luo, G., Zhang, Y., Li, S., Fan, Y., Fang, S., Wang, P., Li,L. （Corresponding author）. (2021) Generation and Effect Testing of a SARS-CoV-2 RBD-Targeted Polyclonal Therapeutic Antibody Based on Airway Organoid Screening System. Frontiers in Immunology. 12:689065 (IF=7.561)
3. Tang, M., Li, S., Wei, L., Qu, J., Li, L. （Corresponding author）. (2021) Do engineered nanomaterials affect immune responses by interacting with gut microbiota? Frontiers in Immunology. 12:684605 (IF=7.561)
4. Yang, M., Li, L.（Co-author）, Huang, T., Li, S., Zhang, M., Yang, Y., Jiang, Y., Li, X., Yuan, J., Liu, Y.. (2021) SARS-CoV-2 Detected on Environmental Fomites for both Asymptomatic and Symptomatic COVID-19 Patients. American Journal of Respiratory and Critical Care Medicine. rccm.202006-2136LE (IF: 21.405)
5. Zhao, F., Yang, Y., Wang, Z., Li, L.（Corresponding author）, Liu, L., Liu, Y.. (2020) The Time Sequences of Oral and Fecal Viral Shedding of Coronavirus Disease 2019 (COVID-19) Patients. Gastroenterology S0016-5085(20)30663-6 (IF: 22.682)
6. Shi, Y., Lin, J., Tao, X., Qu, J., Liao, S., Li, M., Deng, K., Du, P., Liu, K., Thissen, H., Li, L. (Corresponding author), Kingshott, P., and Wang, P-Y. (2021) Harnessing Colloidal Self-Assembled Patterns (cSAPs) to Regulate Bacterial and Human Stem Cell Response at Biointerfaces In Vitro and In Vivo. ACS Appl. Mater. Interfaces. 2021, 13, 18, 20982–20994 (IF: 9.229)
7. Li, L., Chong, H.C., Ng, S.Y., Kwok, K.W., Teo, Z., Tan, E.H.P., Choo, C.C., Seet, J.E., Choi. H.W., Buist, M.L., Chow, V.T.K., Tan, N.S. (2015) Angiopoietin-like 4 increases pulmonary tissue leakiness and damage during influenza pneumonia. Cell Rep. 10(5): 654-663 (IF: 9.423)
8. Li, L.（Corresponding author）,Foo, B.J.W., Kwok, K.W., Sakamoto, N., Mukae, H., Izumikawa, K., Mandard, S., Quenot, J.-P., Lagrost, L., Teh, W.K., Kohli, G.S., Zhu, P., Choi, H., Buist, M.L., Yang, L., He, F., Chow, V.T.K., Tan, N.S.. (2019) Antibody treatment against angiopoietin-like 4 (ANGPTL4) reduces pulmonary edema and injury in secondary pneumococcal pneumonia. mBio 10:e02469-18. (IF: 6.784，中科院小類一區(qū)，TOP期刊)
9. Liang, L., Li, L.（Co-author）, Rong, F.. (2020) Serum Creatinine as a Potential Biomarker for the Diagnosis of Tuberculous Pleural Effusion. Am. J. Med. Sci. (IF: 1.962)
10. Davient, B., Ng, J.P.Z., Xiao, Q., Li, L.（Corresponding author）, and Yang, L..(2018) Comparative Transcriptomics Unravels Prodigiosin's Potential Cancer-Specific Activity Between Human Small Airway Epithelial Cells and Lung Adenocarcinoma Cells. Front. Oncol. 8:573 (IF: 4.848)
11. Iyer, R.L., Li, L. （Co-author ）, Wong, P.S., Sutejo, R., Tan, B.H., and Sugrue, R.J.. (2013) Lovastatin Treatment Mitigates the pro-Inflammatory Cytokine Response in Respiratory Syncytial Virus Infected Macrophage Cells. Antiviral Research 98(2): 332–43. (IF: 4.909)
12. Xu, K., Li, L., Han, Y., Karahan, H.E., Chow, V.T.K., Xu, C. (2017). Cold-chain-free Storable Hydrogel for Infant-friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia. ACS Appl. Mater. Interfaces 9(22):18440-18449. (IF: 9.229).
13. Iyer, R.L., Li, L., Sutejo, R., Chen, H., Wong, P.S., Tan, B.H., and Sugrue, R.J.. (2013) A Systems-Based Approach to Analyse the Host Response in Murine Lung Macrophages Challenged with Respiratory Syncytial Virus. BMC Genomics 14(1): 190. (IF: 3.969)
14. Iyer, R.L., Li, L., Wong, P.S., Brown, G., Tan, B.H., and Sugrue, R.J.. (2013) Increased Hydroxymethylglutaryl Coenzyme A Reductase Activity during Respiratory Syncytial Virus Infection Mediates Actin Dependent Inter-Cellular Virus Transmission. Antiviral Research 100(1): 259–68. (IF: 4.909)
15. Tan, K.S., Yan, Y., Koh, W.L.H., Li, L., Choi, H., Tran, T., Sugrue, R., Wang, D.Y., and Chow, V.T.. (2018) Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures. Front. Microbiol. 9:2685. (IF: 4.076)
16. Teo, Z.Q., Sng, M.K., Chan, J.S.K., Lim, M., Li, Y., Li, L.（李亮）, Phua, T., Lee, J., Tan, Z.W., Zhu, P., Tan, N.S.. (2017) Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial-mesenchymal transition by inducing 14-3-3γ expression. Oncogene 2017.244 (IF: 7.971).
17. Wang, J.K., Luo, B., Guneta, V., Li, L., Foo, S.E.M., Dai, Y., Tan, T.T.Y., Tan, N.S., Choong, C., and Wong, M.T.C.. (2017) Supercritical carbon dioxide extracted extracellular matrix material from adipose tissue. Mater. Sci. Eng. C. 75:349–358. (IF: 5.88).
18. Chan, J.S.K., Tan, M.J., Sng, M.K., Teo, Z., Phua, T., Choo, C.C., Li, L., Zhu, P., and Tan, N.S.. (2017) Cancer-associated fibroblasts enact field cancerization by promoting extratumoral oxidative stress. Cell Death Dis. 8:e2562. (IF: 8.467)