師資
個(gè)人簡介：
賈寧，醫(yī)學(xué)院副教授，博士生導(dǎo)師。入選《麻省理工科技評(píng)論》“35歲以下科技創(chuàng)新35人”亞太區(qū)榜單（2022），美國布拉瓦尼克區(qū)域青年科學(xué)家化學(xué)獎(jiǎng)獲得者（2020）。2016年于中國科學(xué)技術(shù)大學(xué)生命學(xué)院獲得博士學(xué)位， 隨后在美國紀(jì)念斯隆凱特琳癌癥中心從事博士后研究。2021年5月加入南方科技大學(xué)醫(yī)學(xué)院。長期聚焦于細(xì)菌抗噬菌體免疫機(jī)制研究，近年來以通訊作者身份發(fā)表論文15篇 (Science 2025a, 2025b；Nature Chemical Biology 2024；Molecular Cell 2023，2019a, 2019b, 2019c；Nature Communications, 2024a,b, 2022; Nature Reviews Molecular Cell Biology, 2021； Cell Research, 2024, 2022, 2020;等)。其中，Nature Communications, 2022 被世界學(xué)術(shù)組織“Faculty Opinions (原F1000Prime)”推薦；擔(dān)任Nature、Science、Nature Microbiology、Nature Catalysis、Nature Chemical Biology等雜志審稿人。加入Journal of Biological Chemistry (JBC)、mLife期刊作為Editorial Board member。主持國自然面上、省市基金多項(xiàng)。
教育背景：
2006-2010 中國海洋大學(xué)， 海洋生物資源與環(huán)境，學(xué)士
2010-2016 中國科學(xué)技術(shù)大學(xué)，生物化學(xué)與分子生物學(xué)，博士 （導(dǎo)師周叢照、陳宇星教授）
工作經(jīng)歷：
2022.06-至今 南方科技大學(xué)醫(yī)學(xué)院，副教授
2021.05-2022.05 南方科技大學(xué)醫(yī)學(xué)院，助理教授
2017-2021 美國紀(jì)念斯隆凱特琳癌癥中心，博士后 （導(dǎo)師：Dinshaw J. Patel）
獲獎(jiǎng)情況及榮譽(yù)：
2024 入選Journal of Biological Chemistry (JBC)和mLife期刊的Editorial Board member
2022 入選《麻省理工科技評(píng)論》“35歲以下科技創(chuàng)新35人”亞太區(qū)榜單（2022）
2021 深圳海外高層次人才（孔雀B類）
2020 美國布拉瓦尼克區(qū)域青年科學(xué)家化學(xué)獎(jiǎng) (2020 Blavatnik Regional Awards for Young Scientists Winner in Chemistry)
2016 蔡司-斑馬魚科學(xué)研究獎(jiǎng)
2010 山東省優(yōu)秀畢業(yè)生
2007，2009 國家獎(jiǎng)學(xué)金
研究興趣：
1）課題組通過結(jié)合生物化學(xué)、分子生物學(xué)、微生物學(xué)及結(jié)構(gòu)生物學(xué)等手段，探究微生物與宿主免疫系統(tǒng)相互作用的分子機(jī)制，尤其關(guān)注細(xì)菌和古菌免疫防御系統(tǒng)（如CRISPR-Cas適應(yīng)性免疫系統(tǒng)）抵御噬菌體侵染的分子機(jī)制。
2）基于微生物與宿主免疫系統(tǒng)相互作用分子機(jī)制的理解，開發(fā)相應(yīng)的生物技術(shù)工具（如CRISPR-Cas基因編輯工具）。
學(xué)術(shù)任職：
Journal of Biological Chemistry (JBC)、mLife期刊的Editorial Board member
紐約科學(xué)學(xué)會(huì)（The New York Academy of Sciences）會(huì)員
發(fā)表論文：
（#第一作者; *通訊作者 ）
1. Song, X. Y.#; Xia, Y.#; Zhang, J. T.#; Liu, Y. J.; Qi, H.; Wei, X. Y.; Hu, H.;Xia, Y.; Liu, X.; Ma, Y.F.; Jia, N.* (2025). Bacterial reverse transcriptase synthesizes long polyA-rich cDNA for anti-phage defense, Science, 2025 May 1:eads4639. doi: 10.1126/science.ads4639.
2. Hayes, V. M. #; Zhang, J. T.#; Katz, M. A.; Li, Y.; Kocsis, B.; Jia, N.*; Meeske, A. J.* (2025). RNA-mediated CRISPR-Cas13 inhibition via crRNA structural mimicry. Science, 388(6745): 387-391
3. Zhang, J.T.; Wei, X.Y.; Cui, N.; Tian, R. & Jia, N. * (2024). Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology 20, 503-511 .
4. Cui, N.#; Zhang, J.T.#; Li, Z.; Wei, X.Y.; Wang, J. and Jia, N.* (2024). Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system. Nature Communications 15, 8610 .
5. Zhang, J.T.#; Liu, X. Y.#; Li, Z.#;Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H.; Jia, N.* (2024). Structure and genome editing activity of the novel CRISPR-Cas12o1 effector. Cell research. 10.1038/s41422-024-01050-y.
6. Zhang, J.T.#; Liu, X.Y.#; Li, Z.L.#; Wei, X.Y.; Song, X.Y.; Cui, N.; Zhong, J.; Li, H. and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797.
7. Cui, N.#; Zhang, J.T.#; Li, Y.; Liu, Y.; Liu, X.Y.; Wang, C.; Huang, H.* and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.
8. Duan, Z.#; Zhang, X.#; Zhang, J.T.; Li, S; Liu, R.; Sun, J.; Zhao, Q.; Jia, N.; Jia, N.* and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.
9. Cui, N.#; Zhang, J.T.#; Li, Z.; Liu, X.Y.;Wang, C.; Huang, H.* and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549.
10. Patel, D.J.*; Yu, Y. and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.
11. Jia, N.* & Patel, D.J.* (2022). Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877.
12. Jia, N.*; Patel. D. J.* (2021). Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.
13. Meeske A. J.#; Jia, N.#; Cassel A.K.; Kozlova A.; Liao J.; Wiedmann M.; Patel D. J.*; Marraffini L. A.* (2020). A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.
14. Jia, N.*; Xie, W.; De La Cruz, J.M.; Eng, E.T.; Patel, D.J.* (2020). Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.
15. Jia, N.*; Jones, R.; Yang, G.; Ouerfelli, O.; Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.
16. Jia, N.*; Jones, R.; Sukenick, G.; Patel, D.J.* (2019). Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936.
17. Jia, N.*; Mo, C.Y.;Wang, C.; Eng, E.T.; Marraffini, L.A.; Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265.
18. Jia, N.#; Unciuleac, M.#; Xue C.; Greene E.C.; Patel, D.J.*; Shuman, S.* (2019). Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516.
19. Jia, N.; Liu, N.; Cheng, W.; Jiang, Y.L.; Sun, H.; Chen, L.L.; Peng, J.; Zhang, Y.; Ding, Y.H.; Zhang, Z.H.; et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.
20. Chen, L.L.; Xie, J.; Cao, D.D.; Jia, N.; Li, Y.J.; Sun, H.; Li, W.F.; Hu, B.; Chen, Y.; Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.
21. Zhou, K.; Jia, N.; Hu, C.; Jiang, Y.L.; Yang, J.P.; Chen, Y.; Li, S.; Li, W.F.; Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229.
22. Song, N.; Jia, N.; Yanagimoto, T.; Lin, L.; Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.
23. He, Y.X.; Zhang, N.N.; Li, W.F.; Jia, N.; Chen, B.Y.; Zhou, K.; Zhang, J.; Chen, Y.; Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207.