師資
個(gè)人簡(jiǎn)介：
南方科技大學(xué)醫(yī)學(xué)院教授，博士生導(dǎo)師、教育部高層次青年人才入選者。2009年博士畢業(yè)于西北大學(xué)，2011年3月至2014年3月在芝加哥大學(xué)從事博士后訓(xùn)練，2014年3月至2021年8月就職于西北大學(xué)，教授，博士生導(dǎo)師。獲得國(guó)家自然科學(xué)優(yōu)秀青年基金、面上（3項(xiàng)）及陜西省創(chuàng)新團(tuán)隊(duì)等項(xiàng)目資助，發(fā)表論文50余篇，包括Nat Commun, Sci Adv, PNAS, EMBO J, PLoS Biol, eLife, Cell Rep, Nucleic Acids Res等。于2021年9月加入南方科技大學(xué)醫(yī)學(xué)院。研究方向?yàn)槲⑸锕δ芑蚪M學(xué)以及病原菌致病和耐藥機(jī)制。
教育背景：
1999. 9-2003. 7 江西農(nóng)業(yè)大學(xué) 本科
2003. 9-2006. 7 西北大學(xué)（中國(guó)） 碩士
2006. 9-2009. 7 西北大學(xué)（中國(guó)） 博士
工作經(jīng)歷：
2009. 7-2011. 2 西北大學(xué) 講師
2011 .3-2014. 3 芝加哥大學(xué) 博士后
2014. 4-2021. 9 西北大學(xué) 教授
獲獎(jiǎng)情況及榮譽(yù)：
西北大學(xué)優(yōu)秀教師 （2018年）
西北大學(xué)優(yōu)秀共產(chǎn)黨員 （2016年）
研究領(lǐng)域：
病原微生物功能基因組學(xué)；病原菌致病和耐藥機(jī)制；合成生物學(xué)；新型抗菌藥物的篩選
學(xué)術(shù)任職：
中國(guó)微生物學(xué)會(huì)醫(yī)學(xué)微生物與免疫學(xué)專業(yè)委員會(huì)委員
中華醫(yī)學(xué)會(huì)微生物與免疫學(xué)青年委員會(huì)委員
《遺傳》編委
陜西省抗感染藥物藥理專業(yè)委員會(huì)副主任委員
陜西省微生物學(xué)會(huì)常務(wù)理事
陜西省健康促進(jìn)與教育協(xié)會(huì)檢驗(yàn)醫(yī)學(xué)專業(yè)委員會(huì)副主任委員
發(fā)表論文：
1. Feifei Chen*, Qingmin Zhao, Ziqiong Yang, Rongrong Chen, Huiwen Pan, Yanhui Wang, Huan Liu, Qiao Cao, Jianhua Gan, Xia Liu, Naixia Zhang, Cai-Guang Yang, Haihua Liang*, Lefu Lan*. (2024) Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus, PLoS Pathog. 20, e1012425.
2. Shuai Le, Leilei Wei, Jing Wang, Fang Tian, Qian Yang, Jingru Zhao, Zhuojun Zhong, Jiazhen Liu, Xuesong He, Qiu Zhong, Shuguang Lu, Haihua Liang*. (2024) Bacteriophage protein Dap1 regulates evasion of antiphage immunity and Pseudomonas aeruginosa virulence impacting phage therapy in mice. Nat Microbiol 9, 1828-1841.
3. Xueliang Zhan, Kuo Zhang, Chenchen Wang, Qiao Fan, Xiujia Tang, Xi Zhang, Ke Wang, Yang Fu, Haihua Liang*. (2024) A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa, Nat Commun. 15, 1860.
4. Yunfu Lu, Feifei Chen, Qingmin Zhao, Qiao Cao, Rongrong Chen, Huiwen Pan, Yanhui Wang, Haixin Huang, Ruimin Huang, Qian Liu, Min Li, Taeok Bae, Haihua Liang*, Lefu Lan* (2023). Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO. Nat Commun, 14(1): 1594
5. Guoyan Cui, Yixi Zhang, Xuejie Xu, Yingying Liu, Zhuang Li, Min Wu, Jianling Liu*, Jianhua Gan*, Haihua Liang* (2022) PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa. Sci Adv, 8(49): eadd4220
6. Xuejie Xu, Yunfang Yan, Jiadai Huang, Zihao Zhang, Zhihan Wang, Min Wu, Haihua Liang* (2022) Regulation of uric acid and glyoxylate metabolism by UgmR protein in Pseudomonas aeruginosa. Environ Microbiol, 24(7): 3242-3255
7. Gukui Chen, Jiashen zhou, Yili Zuo, Weiping Huo, Juan Peng, Meng Li, Yani Zhang, Tietao Wang, Lin Zhang, Liang Zhang*, and Haihua Liang* (2021) Structural basis for diguanylaste cyclase activation by its binding partner in Pseudomonas aeruginosa. Elife, 10: e67289
8. Tietao wang, Xiao Du, Linxuan Ji, Yuying Han, Jing Dang, Jing Wen, Yarong Wang, Qinqin Pu, Min Wu, and Haihua Liang* (2021) Pseudomonas aeruginosa T6SS-mediated molybdate transport contributes to bacterial competition during anaerobiosis. Cell Rep. 35, 108957
9. Juan Peng, Gukui Chen, Xuejie Xu, Tietao Wang, Haihua Liang* (2020) Iron facilitates the RetS-Gac-Rsm cascade to inversely regulate protease IV (piv) expression via the sigma factor PvdS in Pseudomonas aeruginosa. Environ Microbiol. 22(12): 5402-5413.
10. Hongying Jiao, Fan Li, Tietao Wang, Joey Kuok Hoong Yam, Liang Yang, Haihua Liang* (2020) The Pyocin regulator PrtR regulates virulence expression of Pseudomonas aeruginosa by modulation of Gac/Rsm system and c-di-GMP signaling pathway. Infec Immun. 00602-20.
11. Tietao Wang, Yihang Qi, Zhihan Wang, Jingru Zhao, Linxuan Ji, Jun Li, Zhao Cai, Liang Yang, Min Wu, Haihua Liang* (2020) Coordinated regulation of anthranilate metabolism and bacterial virulence by the GntR family regulator MpaR in Pseudomonas aeruginosa. Mol Microbiol. 114: 857-869
12. Tietao Wang, Zhaoyu Hu, Xiao Du, Jing Dang, Yue Shi, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, Min Wu, Haihua Liang* (2020) A type VI secretion system delivers a cell wall amidase to target bacterial competitors. Mol Microbiol, 114(2): 308-321.
13. Gukui Chen, Jianhua Gan, Chun Yang, Yili Zuo, Juan Peng, Meng Li, Weiping Huo, Yingpeng Xie, Yani Zhang, Tietao Wang, Xin Deng, Haihua Liang* (2020) The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa. EMBO J, 39(6): e103412.
14. Yuying Han, Tietao Wang, Gukui Chen, Qinqin Pu, Qiong Liu, Yani Zhang, Linghui Xu, Min Wu, Haihua Liang* (2019) A Pseudomonas aeruginosa type VI secretion system regulated by CueR facilitates copper acquisition. PLoS Pathog, 15(12): e1008198.
15. Yaqin Song, Chun Yang, Gukui Chen, Chao Zhang, Yani Zhang, Jianhua Gan*, Haihua Liang* (2019) Structural and functional analysis of a cysteine biosynthetic regulator CysB controlling bacterial virulence in Pseudomonas aeruginosa. Mol Microbiol, 111(5): 1195-1210
16. Huaping Kang, Jianhua Gan, Jingru Zhao, Weina Kong, Jing Zhang, Miao Zhu, Fan Li, Yaqin Song, Jin Qin and Haihua Liang* (2017). Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing. Nucleic Acids Res. 45 (2): 699-710.
17. Jingru Zhao, Xiang Yu, Miao Zhu, Huaping Kang, Jinbiao Ma, Jianhua Gan*, Xin Deng* and Haihua Liang* (2016). Structural and molecular mechanism of CdpR involved in quorum-sensing and bacterial virulence in Pseudomonas aeruginosa. PLoS Biol. 14 (4): e1002449.
18. Weina Kong, Jingru Zhao, Huaping Kang, Miao Zhu, Xin Deng* and Haihua Liang* (2015). ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa. Nucleic Acids Res. 43 (17): 8268-8282.
19. Haihua Liang*, Xin Deng, Yan Ye and Min Wu* (2014). Molecular mechanism of master regulator VqsM mediating quorum-sensing and antibiotic resistance in Pseudomonas aeruginosa. Nucleic Acids Res. 42 (16): 10307-10320.
20. Haihua Liang, Xin Deng, Mike Bosscher, Quanjiang Ji, Mark P. Jensen and Chuan He* (2013). Engineering Bacterial two-component system PmrA/PmrB sense lanthanide ions. J Am Chem Soc. 135(6): 2037-2039.
21. Xin Deng1, Haihua Liang1, Chuan He, Lefu Lan* and Xiaoyan Tang* (2014). Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 42 (18): 11472-11486.
22. Fei Sun1, Haihua Liang1, Xiangqian kong, Sherrie Xie, Hoonsik Cho, Xin Deng, Quanjiang Ji, Haiyan Zhang, Sophie Alvarez, Leslie M. Hicks, Taeok Bae, Cheng Luo, Hualiang Jiang and Chuan He* (2012). Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci USA. 109 (23): 9095-9100.
23. Pan Gao, Kai Guo, Qinqin Pu, Zhihan Wang, Ping Lin, Shugang Qin, Nadeem Khan, Junguk Hur, Haihua Liang*, Min Wu* (2020) OprC impairs host defense by increasing the quorum sensing-mediated virulence of Pseudomonas aeruginosa. Front Immunol. 11: 1696.
24. Gukui Chen, Haihua Liang* (2020) A novel c-di-GMP signal system regulates biofilm formation in Pseudomonas aeruginosa. Microb cell, 7(6): 160-161.
25. Yani Zhang, Meng Li, Congcong Guan, Yun Zhou, Juan Peng, Haihua Liang* (2020) Genomic characterisation of clinical Pseudomonas aeruginosa isolates PAG5 with a mutidrug-resistant megaplasmid from China. J Glob Antimicrob Resist. 21: 130-131.
26. Yani Zhang, Chao Zhang, Xiao Du, Yun Zhou, Weina Kong, Gee W Lau, Gukui Chen, Gurjeet Singh Kohli, Liang Yang, Tietao Wang, Haihua Liang* (2019) Glutathione activates Type III secretion system through Vfr in Pseudomonas aeruginosa. Front Cell Infect Microbiol, 9: 164
27. Ping Ling, Qinqin Pu, Guanwang Shen, Rongfeng Li, Kai Guo, Chuanmin Zhou, Haihua Liang*, Jianxin Jiang*, Min Wu* (2019) CdpR inhibits CRISPR-Cas adaptive immunity to lower anti-viral defense while avoiding self-reactivity. iScience, 13: 55-68.
28. Xiaolong Shao, Xiaoning Zhang, Yingchao Zhang, Miao Zhu, Pan Yang, Jian Yuan, Yingpeng Xie, Tianhong Zhou, Wei Wang, Sheng Chen, Haihua Liang*, Xin Deng* (2018) RpoN-dependent direct regulation of quorum sensing and the type VI secretion system in Pseudomonas aeruginosa PAO1, J Bacteriol, 200(16): e00205-18.
29. Jingru Wang, Xiaolong Shao, Yingchao Zhang, Yanan Zhu, Pan Yang, Jian Yuan, Tingting Wang, Chunyan Yin, Wei Wang, Sheng Chen, Haihua Liang*, Xin Deng* (2018) HrpS is a global regulator on Type III secretion system (T3SS) and non-T3SS genes in Pseudomonas savastanoi pv. phaseolicola. Mol Plant Microbe Interact, 31(12): 1232-1243.
30. Qinqin Pu, Changpei Gan, Rongpeng Li, Yi Li, shirui Tan, Xuefeng Li, Yuquan Wei, Lefu Lan, Xin Deng, Haihua Liang*, Feng Ma*, Min Wu* (2017) Atg7 deficiency intensifies inflammasome activation and pyroptosis in Pseudomonas sepsis. J Immunol, 198(8): 3205-3213.
31. Miao Zhu, Jingru Zhao, Huaping Kang, Weina Kong and Haihua Liang* (2016). Modulation of type III secretion system in Pseudomonas aeruginosa: Involvement of the PA4857 gene product. Front Microbiol. 28 (7): 1-7.
32. Haihua Liang*, Xin Deng, Quanjiangji, Tuo Shen and Chuan He (2012). The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. J Bacteriol. 194 (12): 3098-3108.
33. Haihua Liang, Lingling LI, Zhaolin Dong, Michael G. Surette and Kangmin Duan* (2008). The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J Bacteriol. 190 (18): 6217-6227.
34. Qiao Cao, Nana Yang, Yanhui Wang, Chenchen Xu, Xue Zhang, Ke Fan, Feifei Chen, Haihua Liang, Yingchao Zhang, Xin Deng, Youjun Feng, Cai-guang Yang, Min Wu, Taeok Bae, Lefu Lan (2020) Mutation-induced remodeling of the BfmRS two-component system in Pseudomonas aeruginosa clinical isolates. Sci Signal. 13 (656) eaaz1529.
35. Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Hualiang Jiang and Chuan He* (2012). Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol. 8 (4): 328-330.
36. Xin Deng, Eranthie Weerapana, Haihua Liang, Quanjiang ji, Yan Ye, Ye Fu, Lu Zhou, Jiaxin Li, Chu Wang, Sophie AlvareZ, Leslie M. Hicks, Lefu Lan, Min Wu, Benjamin F. Cravatt* and Chuan He* (2013). Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host & Microbe. 13: 358-370.
37. Quanjiang Ji, Liang Zhang, Marcus B. Jones, Fei Sun, Xin Deng, Haihua Liang, Hoonsik Cho, Pedro Brugarolas, Yihe N. Gao, Scott N. Peterson, Lefu Lan, Taeok Bae and Chuan He* (2013). Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci USA. 110 (13): 5010-5015.