師資
李凱,現(xiàn)任南方科技大學(xué)生物醫(yī)學(xué)工程系副教授,研究員,博士生導(dǎo)師。主要研究方向?yàn)樾滦凸鈱W(xué)探針的開(kāi)發(fā)及其在活體成像中的應(yīng)用。李凱于2011年在新加坡國(guó)立大學(xué)獲得博士學(xué)位并獲得了國(guó)家優(yōu)秀自費(fèi)留學(xué)生獎(jiǎng)學(xué)金,隨后加入新加坡科技研究局材料與工程研究院任研究科學(xué)家,2013年獲得新加坡科技研究局年輕研究員職業(yè)發(fā)展獎(jiǎng),2015-2017年作為訪問(wèn)學(xué)者加入斯坦福大學(xué)醫(yī)學(xué)院分子影像中心進(jìn)行合作研究。迄今于Adv. Mater.、Angew. Chem. Int. Ed.、ACS Nano、CCS Chem.等期刊發(fā)表學(xué)術(shù)論文100余篇,總引用10,000余次,當(dāng)前H-index為55(Google Scholar)??蒲谐晒@得了國(guó)內(nèi)外同行的廣泛認(rèn)可,連續(xù)入選全球前2%頂尖科學(xué)家“終身科學(xué)影響力排行榜”。申請(qǐng)11項(xiàng)發(fā)明專利并有7項(xiàng)已獲得授權(quán),主持國(guó)家自然科學(xué)基金委員會(huì)聯(lián)合基金重點(diǎn)支持項(xiàng)目等,并參與科技部國(guó)家重點(diǎn)研發(fā)計(jì)劃等項(xiàng)目。
教育背景
1999年-2003年 北京化工大學(xué)材料科學(xué)與工程學(xué)院 本科
2004年-2006年 忠南國(guó)立大學(xué)高分子工學(xué)系 碩士
2008年-2011年 新加坡國(guó)立大學(xué)化學(xué)與生物分子系 博士
工作經(jīng)歷
2018年-至今 南方科技大學(xué)生物醫(yī)學(xué)工程系 副教授
2015年-2017年 斯坦福大學(xué)醫(yī)學(xué)院分子影像中心 訪問(wèn)學(xué)者
2011年-2018年 新加坡科研局材料工程研究院 研究科學(xué)家, PI
榮譽(yù)及獎(jiǎng)勵(lì)
2018年 國(guó)家特聘專家(青年)
2016年 世界分子影像大會(huì)Travel Award
2015年 新加坡科技研究局International Fellowship
2013年 新加坡科技研究局年輕研究員職業(yè)發(fā)展獎(jiǎng)
2011年 教育部?jī)?yōu)秀自費(fèi)留學(xué)生獎(jiǎng)學(xué)金
2008年 新加坡國(guó)立大學(xué)校長(zhǎng)獎(jiǎng)學(xué)金
2004年 韓國(guó)科技財(cái)團(tuán)優(yōu)秀外國(guó)留學(xué)生獎(jiǎng)學(xué)金
2003年 北京地區(qū)高校優(yōu)秀畢業(yè)生
代表論文
1. Huaxiao Yang,* Xulei Qin, Huiyuan Wang, Xin Zhao, Yonggang Liu, Hung-Ta Wo, Chun Liu, Masataka Nishiga, Haodong Chen, Jing Ge, Nazish Sayed, Oscar J. Abilez, Dan Ding, Sarah C. Heilshorn, Kai Li.* An in vivo miRNA delivery system for restoring infarcted myocardium. ACS Nano 2019, 13, 9880-9894.
2. Jen-Shyang Ni, Tianliang Min, Yaxi Li, Menglei Zha, Pengfei Zhang, Chun Loong Ho, Kai Li.* Planar AIEgens with enhanced solid-state luminescence and ROS-generation for multidrug-resistant bacteria treatment. Angew. Chem. Int. Ed. 2020, 59, 10179-10185.
3. Xuanyu Li, Menglei Zha, Yaxi Li, Jen-Shyang Ni, Tianliang Min, Tianyi Kang, Guang Yang, Hao Tang, Kai Li,* Xingyu Jiang.* Sub-10 nm aggregation-induced emission quantum dots assembled by microfluidics for enhanced tumor-targeting and reduced retention in the liver. Angew. Chem. Int. Ed. 2020, 59, 21899-21903. (Hot Paper)
4. Menglei Zha, Xiangwei Lin, Jen-Shyang Ni,* Yaxi Li, Yachao Zhang, Xun Zhang, Lidai Wang,* Kai Li.* An ester-substituted semiconducting polymer with efficient nonradiative decay enhances NIR-II photoacoustic performance for monitoring of tumor growth. Angew. Chem. Int. Ed. 2020, 59, 23268-23276.
5. Jen-Shyang Ni, Xun Zhang, Guang Yang, Tianyi Kang, Xiangwei Lin, Menglei Zha, Yaxi Li, Lidai Wang, Kai Li.* A photoinduced nonadiabatic decay-guided molecular motor triggers effective photothermal conversion for hyperthermia cancer therapy. Angew. Chem. Int. Ed. 2020, 59, 11298-11302.
6. Zonghai Sheng, Yaxi Li, Dehong Hu, Tianliang Min, Duyang Gao, Jen-Shyang Ni, Pengfei Zhang, Yuenan Wang, Xin Liu, Kai Li,* Hairong Zheng,* Ben Zhong Tang.* Centimeter-deep NIR-II fluorescence imaging with nontoxic AIE probes in non-human primates. Research 2020, 2020, 4074593.
7. Guang Yang, Jen-Shyang Ni, Yaxi Li, Menglei Zha, Yao Tu, Kai Li.* Acceptor engineering for optimized ROS generation facilitates reprogramming macrophages to M1 phenotype in photodynamic immunotherapy. Angew. Chem. Int. Ed. 2021, 60, 5386-5393. (Hot Paper, Highly Cited)
8. Tianyi Kang, Jen-Shyang Ni, Tingting Li, Jun Wang, Zeshun Li, Yaxi Li, Menglei Zha, Chen Zhang, Xue Wu, Heng Guo, Lei Xi, Kai Li.* Efficient and precise delivery of microRNA by photoacoustic force generated from semiconducting polymer-based nanocarriers. Biomaterials 2021, 275, 120907.
9. Guang Yang, Song-Bo Lu, Chong Li, Feng Chen, Jen-Shyang Ni, Menglei Zha, Yaxi Li, Ji Gao, Tianyi Kang, Chao Liu, Kai Li.* Type I macrophage activator photosensitizer against hypoxic tumor. Chem. Sci. 2021, 12, 14773-14780.
10. Cheng Zhou, Zeshun Li, Ziyue Zhu, Geraldine W. N. Chia, Alexander Mikhailovsky, Ricardo Javier Vázquez, Samuel J. W. Chan, Kai Li,* Bin Liu,* Guillermo C. Bazan.* Conjugated oligoelectrolytes for long-term tumor tracking with incremental NIR-II emission. Adv. Mater. 2022, 34, 2201989.
11. Jun Wang, Qinzhen Li, Hui Zhao, Wentong Yue, Kaiwen Zhang, Xingyu Jiang,* Kai Li.* Facile and controllable synthesis of the renal-clearable “l(fā)uminous pearls” for in vivo afterglow/magnetic resonance imaging. ACS Nano 2022, 16, 462-472.
12. Yaxi Li, Menglei Zha, Tianyi Kang, Chong Li, Xue Wu, Shuxian Wang, Song-Bo Lu, Yi-Shan Lee, Yun-Rong Wu, Jen-Shyang Ni,* Kai Li.* Promoted NIR-II fluorescence by heteroatom-inserted rigid-planar cores for monitoring cell therapy of acute lung injury. Small 2022, 18, 2270006.
13. Jun, Wang, Menglei Zha, Hui Zhao, Wentong Yue, Decheng Wu, Kai Li.* Detection of kidney dysfunction through in vivo magnetic resonance imaging with renal-clearable gadolinium nanoprobes. Anal. Chem. 2022, 94, 4005-4011.
14. Chong Li, Minghao Han, Ji Gao, Shuxian Wang, Song-Bo Lu, Yaxi Li, Zhao Liu, Chen Zhang, Zhaojin Wang, Fangliang Wang, Yang Sun, Chun Loong Ho, Kai Wang, Yun Shen, Kai Li.* Enhancing photodynamic inactivation via tunning spatial constraint on photosensitizer. Sci. China Chem. 2024, 67, 652-663.
15. Yingying Meng, Ji Gao, Peirong Zhou, Xudong Qin, Miao Tian, Xiaohui Wang, Cheng Zhou,* Kai Li,* Fei Huang,* Yong Cao. NIR-II conjugated electrolytes as biomimetics of lipid bilayers for in vivo liposome tracking. Angew. Chem. Int. Ed. 2024, e202318632.
16. Ji Gao, Weijun Wu, Lulu Zhou, Shaokuan Gong, Chong Li, Xihan Chen,* Yiming Li,* Kai Li.* Facile blinking dyes with spontaneous enol-keto tautomerism for super-resolution imaging of subcellular targets. CCS Chem. 2024, doi: 10.31635/ccschem.024.202303818.