師資
個(gè)人簡(jiǎn)介：
2009年在南昌大學(xué)獲得醫(yī)學(xué)學(xué)士學(xué)位，2015年獲得北京大學(xué)博士學(xué)位，2015年至2019年在清華大學(xué)從事博士后研究，2020年初受聘于南方科技大學(xué)生命科學(xué)學(xué)院；深圳市高層次人才，廣東省珠江人才（青年拔尖人才）。以第一作者或者通訊作者身份在Cell、Cell Research、Nature Chemical Biology、Nucleic Acids Research、Nature Communications、PNAS、Communications Biology、Protein & Cell 等國際權(quán)威期刊發(fā)表多篇研究性論文。擔(dān)任Molecular Cell，Science Advances，Nature Communications，Cell Reports，Structure等國際著名期刊獨(dú)立審稿人。
研究領(lǐng)域：
課題組主要通過冷凍電子顯微學(xué)、液液相分離、生物化學(xué)、分子生物學(xué)、細(xì)胞生物學(xué)等技術(shù)手段，從抗病毒先天免疫分子機(jī)制、新型抗病毒藥物開發(fā)、及病毒多藥耐藥分子機(jī)制解析等三個(gè)方面，研究病毒與宿主的攻防關(guān)系，為預(yù)防、治療病毒性疾病提供重要的理論基礎(chǔ)和新思路。
工作經(jīng)歷：
2019至今 南方科技大學(xué)生物系 助理教授
2015-2019 清華大學(xué)生命科學(xué)學(xué)院 博士后
學(xué)習(xí)經(jīng)歷：
2009-2015 北京大學(xué)醫(yī)學(xué)部 基礎(chǔ)醫(yī)學(xué)院 博士
2004-2009 南昌大學(xué) 第四臨床醫(yī)學(xué)院 學(xué)士
代表文章：
1.Mu, J.Q.#, Wu, C.#, Xu, K.M, Liu, X.G., Fu, Y.J. Zhang, Z., Yu J.W., Xue, C.Y., Wang, Z., Chen, X.M., Chen, Y.H.,Ou, G.S.*, Liu, Z.M.*. (2025). Conformational Reorganization and Phase Separation Drive Hyper-Editing of ADR-2-ADBP-1 Complex, Nucleic Acids Research, (Accepted, 最后共同通訊作者). 實(shí)驗(yàn)室2021級(jí)博士生穆建強(qiáng)、2020級(jí)碩士吳藏為本文共同第一作者。
2.Yang J#, Wang T.Y.#, Huang Y#, Li X.Z, Long Z.Y., Zhang S.Q., Zhang L.L., Liu Z.K., Sun H.B., Zhang M.J., Yin H, Liu, Z.M.*, Heng Zhang*. (2025). Structural insights into the target recognition mechanism of the compact Cas9d. Nature Communications, (Accepted,共同通訊作者)。實(shí)驗(yàn)室2020級(jí)博士生黃穎為本文共同第一作者。
3.Liu J#, Wu C#, Liu Y.Y, Chen Q.G., Ding Y.Z., Lin Z.Q., Pan L.F., Xiao K, Li J.C.*, Liu, Z.M.*, Liu W*. (2025). Structural insights into the Dual Ca2+-Sensor-Mediated Activation of the PPEF Phosphatase Family, Nature Communications, (Accepted,共同通訊作者)。實(shí)驗(yàn)室2020級(jí)碩士吳藏為本文共同第一作者。
2024年
1. Chenyang Xue, Junshan Tian, Yanhong Chen, Zhongmin Liu*; Structural insights into human ELAC2 as a tRNA 3' processing enzyme, Nucleic Acids Research, 2024, (研究性論文) （唯一通訊作者，2022級(jí)博士生薛晨陽為唯一第一作者）。
2. Kun Liu#, Cang Wu#, Mingyue Zhu#, Junnv Xu#, Bo Lin, Haifeng Lin, Zhongmin Liu* & Mengsen Li*，Structural characteristics of alpha- fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites, Communications Biology, 2024, 7:505, (研究性論文) （共同通訊作者）實(shí)驗(yàn)室訪問學(xué)生劉坤博士、2020級(jí)碩士生吳藏為本文共同第一作者。
3. Ying Huang#, Chenyang Xue#, Ruiqian Bu#, Cang Wu#, Jiachen Li, Jinqiu Zhang, Jinyu Chen, Zhaoying Shi, Yonglong Chen, Yong Wang*, Zhongmin Liu*; Transport mechanism and peptide inhibitor of the autoinhibited ABC transporter, hMRP5, Nature Communications,2024, (研究性論文, Highlighted by Nature Communications Editor-https://www.nature.com/ncomms/editorshighlights) （最后共同通訊作者）實(shí)驗(yàn)室2020級(jí)博士生黃穎、2022級(jí)博士生薛晨陽、2019級(jí)博士生卜瑞倩、2020級(jí)碩士吳藏為本文共同第一作者。
2023年
1. Lulu Guo#; Yumu Zhang#; Guoxing Fang#; Lu Tie#; Yuming Zhuang#; Chenyang Xue#; Qi Liu; Minghui Zhang; Kongkai Zhu; Chongzhao You; Peiyu Xu; Qingning Yuan; Chao Zhang; Lei Liu; Naikang Rong; Shengxuan Peng; Yuan Liu; Chuanzheng Wang; Xin Luo; Zongyao Lv; Dongwei Kang; Xiao Yu; Cheng Zhang; Yi Jiang; Xinzhong Dong*; Jiuyao Zhou*; Zhongmin Liu*; Fan Yang*; Eric Xu*; Jin-Peng Sun*; Ligand recognition and G protein coupling of the human itch receptor MRGPRX1, Nature Communications, 2023, 14(5004). (研究性論文) （共同通訊作者）實(shí)驗(yàn)室2022級(jí)博士生薛晨陽為本文共同第一作者。
2. Shen-Ming Huang#; Meng-Yao Xiong#; Lei Liu#; Jianqiang Mu#; Ming-Wei Wang#; Ying-Li Jia#; Kui Cai#; Lu Tie; Chao Zhang; Sheng Cao; Xin Wen; Xiaoyan Zhang*; Zhongmin Liu*; Bao-Xue Yang*; Yang Du*; Jin-Peng Sun*; Single hormone or synthetic agonist induce Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths, proceedings of the national academy of sciences of the united states of America （PNAS）, 2023, 120(30): e2216329120. (研究性論文)（共同通訊作者）實(shí)驗(yàn)室2021級(jí)博士生穆建強(qiáng)為本文共同第一作者。
3. Mengqi Wu#; Cang Wu#; Tiefeng Song#; Kewu Pan; Yong Wang*; Zhongmin Liu*; Structure and transport mechanism of the human calcium pump SPCA1, Cell Research, 2023, 33(7): 533-545. (研究性論文) （共同通訊作者）實(shí)驗(yàn)室2020級(jí)碩士武夢(mèng)琪、吳藏為本文共同第一作者。
4. Huang Ying#; Xue Chenyang#; Wang Liangdong; Bu Ruiqian; Mu Jianqiang; Wang Yong*; Liu Zhongmin*; Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4., Communications Biology, 2023, 6(1). (研究性論文) （共同通訊作者）實(shí)驗(yàn)室2020級(jí)博士生黃穎、2022級(jí)博士生薛晨陽為本文共同第一作者。
5. Mu Jianqiang#; Xue Chenyang#; Fu Lei#; Yu Zongjun; Nie Minhan; Wu Mengqi; Chen Xinmeng; Liu Kun; Bu Ruiqian; Huang Ying; Yang Baisheng; Han Jianming; Jiang Qianru; Chan Kevin C; Zhou Ruhong; Li Huilin; Huang Ancheng; Wang Yong*; Liu Zhongmin*; Conformational cycle of human polyamine transporter ATP13A2., Nature Communications, 2023, 14(1). (研究性論文) （共同通訊作者）實(shí)驗(yàn)室2021級(jí)博士生穆建強(qiáng)、2022級(jí)博士生薛晨陽為本文共同第一作者。
6. Zheng, Liming; Liu, Nan*; Gao, Xiaoyin; Zhu, Wenqing; Liu, Kun; Wu, Cang; Yan, Rui; Zhang, Jincan; Gao, Xin; Yao, Yating; Deng, Bing; Xu, Jie; Lu, Ye; Liu, Zhongmin; Li, Mengsen; Wei, Xiaoding*; Wang, Hong-Wei*; Peng, Hailin*; Uniform thin ice on ultraflat graphene for high-resolution cryo-EM, Nature Methods, 2023, 20(1): 123-+. (研究性論文) 實(shí)驗(yàn)室訪問學(xué)生劉坤、2020級(jí)碩士吳藏參與本文工作。
2022年
1. Lin, Hui; Xiao, Peng; Bu, Rui-Qian; Guo, Shengchao; Yang, Zhao; Yuan, Daopeng; Zhu, Zhong-Liang; Zhang, Chuan-Xin; He, Qing-Tao; Zhang, Chao; Ping, Yu-Qi; Zhao, Ru-Jia; Ma, Chuan-Shun; Liu, Chang-Hao; Zhang, Xiao-Ning; Jiang, Dan; Huang, Shaohui; Xi, Yue-Tong; Zhang, Dao-Lai; Xue, Chen-Yang; Yang, Bai-Sheng; Li, Jian-Yuan; Lin, Hao-Cheng; Zeng, Xu-Hui; Zhao, Han; Xu, Wen-Ming; Yi, Fan*; Liu, Zhongmin*; Sun, Jin-Peng*; Yu, Xiao*; Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms, Nature Chemical Biology, 2022, 18(11): 1196-+. (研究性論文) （共同通訊作者）實(shí)驗(yàn)室2019級(jí)博士生卜瑞倩為本文共同第一作者。
2020年
1. Yuan, Daopeng#; Liu, Zhongmin#; Kaindl, Jonas; Maeda, Shoji; Zhao, Jiawei; Sun, Xiaoou; Xu, Jun; Gmeiner, Peter*; Wang, Hong-Wei*; Kobilka, Brian K.*; Activation of the alpha(2B) adrenoceptor by the sedative sympatholytic dexmedetomidine, Nature Chemical Biology, 2020, 16(5): 507-+. (研究性論文) （共同第一作者）
2018年
1. Liu, Zhongmin#; Wang, Jia#; Cheng, Hang#; Ke, Xin#; Sun, Lei; Zhang, Qiangfeng Cliff; Wang, Hong-Wei*; Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate, Cell, 2018, 173(5): 1191-+. (期研究性論文) （共同第一作者）
2017年
1. Guan Zhe; Cai Tiantian; Liu Zhongmin; Dou Yunfeng; Hu Xuesong; Zhang Peng; Sun Xin; Li Hongwei; Kuang Yao; Zhai Qiran; Ruan Hao; Li Xuanxuan; Li Zeyang; Zhu Qihui; Mai Jingeng; Wang Qining; Lai Luhua; Ji Jianguo; Liu Haiguang; Xia Bin; Jiang Taijiao; Luo Shu Jin; Wang Hong Wei; Xie Can*; Origin of the Reflectin Gene and Hierarchical Assembly of Its Protein, Current Biology, 2017, 27(18): 2833-+. (研究性論文)
2016年
1. Qin, Siying#; Yin, Hang#; Yang, Celi; Dou, Yunfeng; Liu, Zhongmin; Zhang, Peng; Yu, He; Huang, Yulong; Feng, Jing; Hao, Junfeng; Hao, Jia; Deng, Lizong; Yan, Xiyun; Dong, Xiaoli; Zhao, Zhongxian; Jiang, Taijiao; Wang, Hong-Wei; Luo, Shu-Jin; Xie, Can*; A magnetic protein biocompass, Nature Materials, 2016, 15(2): 217. (研究性論文)
2015年
1. Liu Zhongmin#; Wang Jia; Li Gang*; Wang Hong Wei*; Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain, Protein & Cell, 2015, 6(3): 185-193. (研究性論文) （第一作者）
2012年
1. Li Chaoying#; Wang Shanshan; Jiang Wei; Li Hui; Liu Zhongmin; Zhang Chao; McNutt Michael A; Li Gang*; Impact of intracellular alpha fetoprotein on retinoic acid receptors-mediated expression of GADD153 in human hepatoma cell lines, International Journal of Cancer, 2012, 130(4): 754-764. (研究性論文)
1. Wang Shanshan; Jiang Wei; Chen Xiangmei; Zhang Chao; Li Hui; Hou Wenting; Liu Zhongmin; McNutt Michael A; Lu Fengmin*; Li Gang*; Alpha-fetoprotein acts as a novel signal molecule and mediates transcription of Fn14 in human hepatocellular carcinoma, Journal of Hepatology, 2012, 57(2): 322-329. (研究性論文)
2011年
1. Li, Mengsen; Li, Hui; Li, Chaoying; Wang, Shanshan; Jiang, Wei; Liu, Zhongmin; Zhou, Sheng; Liu, Xinhua; McNutt, Michael A.; Li, Gang*; Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines, International Journal of Cancer, 2011, 128(3): 524-532. (研究性論文)