個(gè)人簡介：
師偉偉，化學(xué)生物學(xué)系，廖茂富講席教授課題組研究副教授，碩士生導(dǎo)師。
2014 年于中國科學(xué)技術(shù)大學(xué)獲得理學(xué)博士學(xué)位， 2014-2018 期間在香港中文大學(xué)完成博士后研究工作，深圳市高層次海外人才。2019年3月獲得廣東省自然科學(xué)研究系列副高級研究員職稱。長期從事蛋白質(zhì)結(jié)構(gòu)、功能與分子機(jī)制研究，具有扎實(shí)的分子生物、生物化學(xué)和結(jié)構(gòu)生物學(xué)的前沿實(shí)驗(yàn)技術(shù)和豐富的研究經(jīng)驗(yàn)。
研究領(lǐng)域：
1. 新型藥物靶點(diǎn)蛋白的致病分子機(jī)制研究
2. 基于結(jié)構(gòu)與功能的新型藥物發(fā)現(xiàn)和開發(fā)。
代表文章：
1. Lu JQ, Shi WW, Xiao MJ, Tang YS, Zheng YT, Shaw PC*. Lyophyllin, a Mushroom Protein from the Peptidase M35 Superfamily Is an RNA N-Glycosidase. Int J Mol Sci. 2021 Oct 27;22(21):11598.
2. Shou JW, Cheung CK, Gao J, Shi WW*, Shaw PC*. Berberine Protects C17.2 Neural Stem Cells from Oxidative Damage Followed by Inducing Neuronal Differentiation. Front Cell Neurosci. 2019 Sep 3;13:395.
3. Shi WW, Wong KB, Shaw PC*. Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein. Toxins. 2018 Aug 20;10(8):335.
4. Shi WW, Mak AN, Wong KB, Shaw PC*. Structures and Ribosomal Interaction of Ribosome-Inactivating Proteins. Molecules. 2016 Nov 21;21(11):1588.
5. Shi WW, Tang YS, Sze SY, Zhu ZN, Wong KB, Shaw PC*. Crystal Structure of Ribosome-Inactivating Protein Ricin A Chain in Complex with the C-Terminal Peptide of the Ribosomal Stalk Protein P2. Toxins (Basel). 2016 Oct 13;8(10):296.
6. Shi WW#, Jiang YL#, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H*, Chen Y*, Zhou CZ*. Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. J Biol Chem. 2014 Jul 25;289(30):20898-907.
Du Y#, Shi WW#, He YX, Yang YH, Zhou CZ* and Chen Y*. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochem J. 2011; 436:283-9.
