師資
個(gè)人簡(jiǎn)介：
王瑩， 醫(yī)學(xué)院藥理學(xué)系副教授，博士生導(dǎo)師。2017年于復(fù)旦大學(xué)獲得博士學(xué)位，2017-2022年于美國(guó)加州大學(xué)戴維斯分校（University of California，Davis）從事博士后研究。2022年10月加入南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系。通過結(jié)合熒光共振能量轉(zhuǎn)移(FRET)成像，分子生物學(xué)檢測(cè)與多種小動(dòng)物疾病模型，研究新型G-蛋白耦聯(lián)受體（GPCRs）在心臟生理、病理中的作用機(jī)制，以及心力衰竭治療的新靶點(diǎn)、治療新策略。以第一作者身份已在Circulation Research, Cardiovascular Research，Basic Research in Cardiology等心臟領(lǐng)域發(fā)表研究論文十余篇及獲得相關(guān)專利。2021年獨(dú)立主持了美國(guó)心臟病協(xié)會(huì)博士后基金（AHA Postdoctoral Fellowship, $140,752.00），現(xiàn)擔(dān)任AHA基金評(píng)委（AHA grant reviewer）。同時(shí)擔(dān)任Cells客座編輯，以及Advanced Science等多個(gè)雜志審稿人。并于2022年獲得國(guó)家級(jí)人才頭銜。
教育背景：
2008.09-2012.06 貴州大學(xué)，制藥工程專業(yè)學(xué)士
2012.09-2017.06 復(fù)旦大學(xué)，心血管藥理專業(yè)博士
工作經(jīng)歷：
2017.10-2022.9 加州大學(xué)戴維斯分校，博士后研究員
2022.10-至今 南方科技大學(xué)，助理教授
2022/09-2022/11 南方科技大學(xué)，助理教授
2022/12-至今 南方科技大學(xué)，副教授
獲獎(jiǎng)情況及榮譽(yù)：
2012 貴州省優(yōu)秀畢業(yè)生
2012 復(fù)旦大學(xué)博士新生獎(jiǎng)學(xué)金
2013 復(fù)旦大學(xué)交叉學(xué)科優(yōu)秀博士生研究獎(jiǎng)
2014 第9屆PharmSci@亞洲論壇，論文獎(jiǎng)
2015 上海藥理學(xué)會(huì)青年學(xué)者論壇，優(yōu)秀論文獎(jiǎng)
2015 長(zhǎng)三角生命科學(xué)與人類健康論壇，一等獎(jiǎng)
2016 美國(guó)實(shí)驗(yàn)室自動(dòng)化協(xié)會(huì)（SLAS）第5屆年會(huì)Tony B. 學(xué)術(shù)旅行獎(jiǎng)
2017 美國(guó)實(shí)驗(yàn)室自動(dòng)化協(xié)會(huì)（SLAS）第6屆年會(huì)Tony B. 學(xué)術(shù)旅行獎(jiǎng)
2021 美國(guó)心臟學(xué)會(huì) (AHA) 博士后基金
2022 美國(guó)IX ACRE-APS symposium, 2022 AHA BCVS session, 二等獎(jiǎng)
2022 美國(guó)心臟學(xué)會(huì) (AHA) 青年科學(xué)家旅行獎(jiǎng)
研究領(lǐng)域：
1、GPCR納米信號(hào)域（nanodomain）對(duì)心臟生理、病理的調(diào)控機(jī)制研究
2、心力衰竭、心律失常中鈣信號(hào)紊亂的發(fā)生發(fā)展機(jī)制研究
3、多種藥理（Polypharmacology）在心血管藥理中的應(yīng)用
學(xué)術(shù)任職：
2022- Advanced Science (審稿人)
2022- Frontiers in Immunology (審稿人以及特刊主題規(guī)劃員)
2022- Cells,（客座編輯）
2022- American Heart Association (AHA) grant reviewer-in-training （基金評(píng)審）
2021- Frontiers in Microbiology (審稿人)
2022- 深圳市科創(chuàng)委國(guó)際合作項(xiàng)目會(huì)評(píng)專家
2023- British Journal of Pharmacology，審稿人
2023- 廣東省杰出青年項(xiàng)目評(píng)審專家
2023- 教育部青年長(zhǎng)江學(xué)者評(píng)審專家
發(fā)表論文：
1. Xiang W, Lu H, Shen A, Ni H, Wang Y. Nuclear β-adrenergic signaling microdomain alleviates diabetic kidney fibrosis by YAP inactivation. British Journal of Pharmacology (In revision).
2. Wang Y, Zhao M, Liu XH, Xu B, Rivera G, Xiang YK. Nitric oxide synthase isoforms dictate a biased and compartmentalized adrenergic signaling to promote cardiac contractility. (In Revision. JACC: Basic to Translational Science (In revision).
3. Fu Q, Wang Y, Yan C, Xiang YK. Phosphodiesterases in heart and vessels- From Physiology to Diseases. Physiol Rev. 2023.
4. Bing Xu, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yu Zhang, Bingqing Deng, Zhenduo Zhu; Qiuyun Guan, Nipavan Chiamvimonvat, Qingtong Wang, and Yang K. Xiang. HFrEF and HFpEF model-specific remodeling of subcellular PKA signaling at the ryanodine receptors and SERCA2a. Journal of the American Heart Association (In revision).
5. Wenjing Xiang1*, Xingyun Wang1*, Lei Li1, Junhui Zeng1, Haocheng Lu1&, Ying Wang1&, Unveiling Catecholamine Dynamics in Cardiac Health and Disease: Mechanisms, Implications, and Future Perspectives. International Journal of Drug Discovery and Pharmacology 2023.
6. Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y. βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases. Comment on Nassal et al. Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication. Cells 2023, 12, 748. Cells. 2023;12:2186.
7. Deng B, Zhang Y, Zhu C, Wang Y, Weatherford E, Xu B, Liu X, Conway SJ, Abel ED, Xiang YK. Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling. Circ Res. 2023;132:106–108.
8. Xiang W, Zhou N, Li L, Chen F, Li L, Wang Y. βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases. Comment on Nassal et al. Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication. Cells 2023, 12, 748. Cells. 2023;12:2186.
9. Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022;117:37.
10. Wang Y, Zhao M, Shi Q, Xu B, Zhu C, Li M, Mir V, Bers DM, Xiang YK. Monoamine Oxidases Desensitize Intracellular β1AR Signaling in Heart Failure. Circ Res. 129 (10), 965-967.
11. Wang Y*, Shi Q*, Li M, Zhao M, Reddy GR, Teoh JP, Xu B, Zhu CQ, Ireton KE, Srinivasan S, Chen SL, Gasser PJ, Bossuyt J, Hell JW, Bers DM, Xiang YK. Intracellular β1-Adrenergic eceptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility. Circ Res. 2020 Nov; DOI: 10.1161/CIRCRESAHA.120.317452.
12. Wang Q, Wang Y, West TM, Liu Y, Reddy GR, Barbagallo F, Xu B, Shi Q, Deng B, Wei W, Xiang YK. Carvedilol induces biased β1 adrenergic receptor-Nitric oxide synthase 3-cyclic guanylyl monophosphate signaling to promote cardiac contractility. Cardiovasc Res. 2020 Sep 21; doi: 10.1093/cvr/cvaa266.
13. Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 adrenergic receptor-CaMKII signaling in heart failure. Circ Res. 2020 Aug 28;127(6):796-810. doi: 10.1161/CIRCRESAHA.119.316319.
14. Reddy GR, West TM, Jian Z, Jaradeh M, Shi Q, Wang Y, Chen-Izu Y, Xiang YK. Illuminating cell signaling with genetically encoded FRET biosensors in adult mouse cardiomyocytes. J Gen Physiol. 2018 Nov 5;150(11):1567-1582. doi: 10.1085/jgp.201812119.
15. Wang Y, Cao Y, Zhu Q, Gu X, Zhu YZ. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.
16. Wang Y, Zhong L, Liu X, Zhu YZ. ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing nox4-derived ROS production and apoptosis. Molecules. 2017 Feb 21;22(2). doi: 10.3390/molecules22020331.
17. Wang Y, Zhang Q, Zhong L, Lin M, Luo X, Liu S, Xu P, Liu X, Zhu YZ. Apoptotic Protease activating factor-1 inhibitor mitigates myocardial ischemia injury via disturbing procaspase-9 recruitment by Apaf-1. Oxid Med Cell Longev. 2017;2017:9747296.
18. Zhang QY, Wang ZJ, Miao L, Wang Y, Chang LL, Guo W, Zhu YZ. Neuroprotective Effect of SCM-198 through stabilizing endothelial cell function. Oxid Med Cell Longev. 2019;2019:7850154.
19. Zhang QY, Wang ZJ, Sun DM, Wang Y, Xu P, Wu WJ, Liu XH, Zhu YZ. Novel Therapeutic effects of leonurine on ischemic stroke: New Mechanisms of BBB Integrity. Oxid Med Cell Longev. 2017;2017:7150376.
20. Xu B, Wang Y, Bahriz SMFM, Zhao M, Zhu C, Xiang YK. Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes. Cell Commun Signal. 2022 Sep 14;20(1):143.