師資
南方科技大學(xué)醫(yī)學(xué)院/前沿生物技術(shù)研究院教授。2016-2022年曾任職中國科學(xué)院分子植物科學(xué)卓越創(chuàng)新中心研究員、博士生導(dǎo)師。2009年北京師范大學(xué)獲得學(xué)士學(xué)位,2014年美國普渡大學(xué)獲得博士學(xué)位,師從朱健康教授。入選第十四批海外引才項(xiàng)目青年組、上海市青年拔尖人才、中國科學(xué)院BR計(jì)劃、上?？萍记嗄?5人引領(lǐng)計(jì)劃入選者、中國科學(xué)院青年英才培育計(jì)劃、鵬城孔雀計(jì)劃,2022年獲得教育部自然科學(xué)二等獎(jiǎng)、2023年獲得山東省科學(xué)技術(shù)獎(jiǎng)一等獎(jiǎng)。主要從事植物中DNA甲基化的分子機(jī)制及果實(shí)發(fā)育中生物學(xué)功能的研究以及植物基因編輯系統(tǒng)的開發(fā)工作,系統(tǒng)闡述了DNA甲基化動(dòng)態(tài)形成的分子機(jī)制,及其在果實(shí)成熟中的生物學(xué)功能。在Molecular Cell、PNAS、Genome Biology、Nature Plants、Developmental Cell等國際權(quán)威期刊發(fā)表SCI論文53篇,通訊/共同通訊作者28篇。主持國家重點(diǎn)研發(fā)等國家級(jí)項(xiàng)目6項(xiàng)。擔(dān)任國際期刊Horticulture Research副主編、JIPB副主編、Plant Direct編委、aBIOTECH編委、植物生理學(xué)報(bào)雜志編委。
教學(xué)和科研成果
1. 系統(tǒng)闡述了DNA甲基化動(dòng)態(tài)形成的分子機(jī)制：發(fā)現(xiàn)了真核生物中第一個(gè)調(diào)控DNA去甲基化的蛋白復(fù)合體(Molecular Cell, 2015); 發(fā)現(xiàn)了首個(gè)激活型組蛋白修飾參與調(diào)控DNA甲基化通路(Nature Communications, 2021；Plant Journal, 2021); 首次闡述了真核生物中DNA甲基化及去甲基化通路在全基因組的拮抗作用(Nature Plants, 2016)。在遺傳學(xué)研究中,植物研究體系一直起到了至關(guān)重要的作用。很多重要保守的遺傳機(jī)制都是首先在植物中發(fā)現(xiàn)的,比如孟德爾定律。在表觀遺傳研究中,DNA甲基化相關(guān)的一系列成果都是首先在植物中被發(fā)現(xiàn)。其中,本課題組的研究對(duì)于廣泛理解在真核生物中DNA甲基化的動(dòng)態(tài)平衡機(jī)制有引領(lǐng)性的作用。
2. 揭示了DNA甲基化在果實(shí)成熟中的重要作用：首次揭示了DNA去甲基化酶在番茄成熟中的必要性(PNAS, 2017; New Phytologist, 2022);率先發(fā)現(xiàn)了DNA甲基化在草莓和柑橘等果實(shí)中的重要作用,及其動(dòng)態(tài)變化的獨(dú)特分子機(jī)制(Genome Biology, 2018; PNAS, 2019)。果實(shí)成熟是生物衰老相關(guān)的重要過程。表觀遺傳調(diào)控果實(shí)成熟是世界范圍內(nèi)新興且有重要意義的研究領(lǐng)域。近年來,表觀遺傳多樣性被認(rèn)為是提供育種中遺傳多樣性的重要途徑之一。本課題組的研究為表觀遺傳多樣性在作物育種中的應(yīng)用提供了重要理論基礎(chǔ),也為研究癌癥發(fā)生和人體衰老中DNA甲基化的動(dòng)態(tài)變化提供了新思路。
代表性論文：
1. Huan Huang; Ruie Liu; Qingfeng Niu; Kai Tang; Bo Zhang; Heng Zhang; Kunsong Chen; JianKang Zhu; Zhaobo Lang; Global increase in DNA methylation during orange fruit development and ripening, Proceedings of the National Academy of Sciences, 2019, 116(4): 1430-1436 (共同通訊作者)
2. Yunduan Li; Yanna Shi; Yichen Li; Jiao Lu; Yunfan Sun; Yuanyuan Zhang; Wenbo Chen; Xiaofang Yang; Donald Grierson; Zhaobo Lang; Guihua Jiang; Kunsong Chen; DNA methylation mediated by RdDM pathway and demethylation affects furanone accumulation through regulation of QUINONE OXIDOREDUCTASE in strawberry, Horticulture Research, 2023, 10(8) (共同通訊作者)
3. Chao Gu; Mao-Song Pei; Zhi-Hua Guo; Lei Wu; Kai-Jie Qi; Xue-Ping Wang; Hong Liu; Zhongchi Liu; Zhaobo Lang; Shaoling Zhang; Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism, Genome Biology, 2024, 25(70)(共同通訊作者)
4. Ying Gao; Yujing Lin; Min Xu; Hanxiao Bian; Chi Zhang; Jingyu Wang; Hanqing Wang; Yaping Xu; Qingfeng Niu; Jinhua Zuo; Da-Qi Fu; Yu Pan; Kunsong Chen; Harry Klee; Zhaobo Lang; Bo Zhang; The role and interaction between transcription factor NAC-NOR and DNA demethylase SlDML2 in the biosynthesis of tomato fruit flavor volatiles, New Phytologist, 2022, 235(5): 1913- 1926(共同通訊作者 )
5. Qingfeng Niu; Siqun Wu; Hongtao Xie; Qi Wu; Ping Liu; Yaping Xu; Zhaobo Lang; Efficient A·T to G·C Base Conversions in Dicots Using Adenine Base Editors Expressed under the Tomato EF1α Promoter, Plant Biotechnology Journal, 2023, 0(0)(唯一通訊作者)
6. Yuyun Zhang; Zijuan Li; Jinyi Liu; Yu’e Zhang; Luhuan Ye; Yuan Peng; Haoyu Wang; HuishanDiao; Yu Ma; Meiyue Wang; Yilin Xie; Tengfei Tang; Yili Zhuang; Wan Teng; Yiping Tong; Wenli Zhang; Zhaobo Lang; Yongbiao Xue; Yijing Zhang; Transposable elements orchestrate subgenome convergent and-divergent transcription in common wheat, Nature Communications, 2022,13(1)(共同通訊作者 )
7. Pei Huang; Huan Huang; Xueqiang Lin; Pan Liu; Lun Zhao; Wen-Feng Nie; Jian-Kang Zhu; Zhaobo Lang; MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation, the Plant Journal, 2021, 108: 347-357(唯一通訊作者 )
8. Qingfeng Niu; Zhe Song; Kai Tang; Lixian Chen; Lisi Wang; Ting Ban; Zhongxin Guo; Chanhong Kim; Heng Zhang; Cheng-Guo Duan; Huiming Zhang; Jian-Kang Zhu; Jiamu Du; Zhaobo Lang; A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation, Nature Communications, 2021, 12(1): 3367-3380 (唯一通訊作者)
9. Yuyun Zhang; Zijuan Li; Yu'e Zhang; Kande Lin; Yuan Peng; Luhuan Ye; Yili Zhuang; Meiyue Wang; Yilin Xie; Jingyu Guo; Wan Teng; Yiping Tong; Wenli Zhang; Yongbiao Xue; Zhaobo Lang; Yijing Zhang; Evolutionary rewiring of the wheat transcriptional regulatory network by lineagespecific transposable elements, Genome Research, 2021, 31(共同通訊作者)
10. Qingfeng Niu; Siqun Wu; Xiaoxuan Yang; Ping Liu; Yaping Xu; Zhaobo Lang; Expanding the Scope of CRISPR/Cas9-Mediated Genome Editing in plants using an xCas9 and Cas9-NG hybrid, Journal of Integrative Plant Biology, 2020, 62(4): 398-402 (唯一通訊作者)
11. Dengguo Tang; Philippe Gallusci; Zhaobo Lang; Fruit development and epigenetic modifications, New Phytologist, 2020, 228: 839-844 (唯一通訊作者 )
12. Jingfei Cheng; Qingfeng Niu; Bo Zhang; Kunsong Chen; Ruihua Yang; Jian-Kang Zhu; Yijing Zhang; Zhaobo Lang; Downregulation of RdDM during strawberry fruit ripening, Genome Biology, 2018, 19(1): 212-226 (共同通訊作者 )
13. Zhaobo Lang; Yihai Wang; Kai Tang; Dengguo Tang; Tatsiana Datsenka; Jingfei Cheng; Yijing Zhang; Avtar K. Handa; Jian-Kang Zhu; Critical roles of DNA demethylation in the activation of ripening-induced genes and inhibition of ripening-repressed genes in tomato fruit, Proceedings of the National Academy of Sciences, 2017, 114(22): 4511-4519 ( 唯一第一作者, 共同通訊作者 )
14. Kai Tang; Zhaobo Lang; Heng Zhang; Jian-Kang Zhu; The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications, Nature Plants, 2016, 2(11): 16169- 16169 (共同第一作者, 唯一通訊作者)
15. Zhaobo Lang; Mingguang Lei; Xingang Wang; Kai Tang; Daisuke Miki; Huiming Zhang; Satendra K. Mangrauthia; Wenshan Liu; Wenfeng Nie; Guojie Ma; Jun Yan; Cheng-Guo Duan; Chuan-Chih Hsu; Chunlei Wang; W. Andy Tao; Zhizhong Gong; Jian-Kang Zhu; The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing, Molecular Cell, 2015, 57(6): 971-983(共同第一作者)